More frequent heat waves are expected to lead to a significant rise in energy demand for cooling buildings. However, the air-conditioning split units that often equip buildings further aggravate the problem by generating waste heat. Cool*Alps aims at improving the climate change adaptability and energy security of the Alpine region by supporting the diffusion of innovative Thermal Activated Buildings (TABs). They enable CO2-free heating and cooling with one system and make settlements more flexible and resilient to extreme heat periods. Cool*Alps will leverage their great potential by developing the competences and supporting decision-makers in implementing TABs.